The presence of beta-amyloid plaques is one of the hallmarks of Alzheimer's disease. Who Plays Nora In Ted Lasso Season 2 (& Why You Haven't Seen … Intellectual and Developmental Symptoms. Down Syndrome If possible, give notice in advance if a usual process will be changed. Signs of Down Syndrome in Babies and Children - Parents This finding has been demonstrated across a number of areas of development including the acquisition of language, motor skills and literacy. Down syndrome causes physical, cognitive (thinking) and behavioral symptoms. This additional chromosome causes some level of intellectual disability and can cause a number of physical and developmental characteristics. Common physical signs of Down syndrome include 1,2: Decreased or poor muscle tone; Short neck, with excess skin at the back of the neck ; Flattened facial profile and nose; Small head, … Kiki May's IMDb page is almost completely bare at the moment, but that is likely to change after her Ted Lasso role.